80P Understanding the patient perspective of small cell lung cancer (SCLC)
نویسندگان
چکیده
منابع مشابه
Lung cancer is divided into two morphological types, small cell lung cancer (SCLC) and non-small cell lung cancer
The p53 protein is one of the best-known tumor suppressors. Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53. In the present study, we found that of 37 NSCLC patients, p53 alterations were detected in 20 tumors (54.1%), the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expr...
متن کاملCharacterization of a new small cell lung cancer (SCLC) cell line STP54 derived from a metastatic bioptate of a combined type of SCLC with Non-SCLC component.
Small cell lung cancer constitutes 15-20% cases of lung cancers, currently the leading cause of death from malignant diseases. It also causes the demise of >90% of affected individuals in 5 years. We have established a new SCLC cell line STP54 derived from fine needle aspirate of metastatic supraclavicular lymph node of 54 -year-old women for model experiments. The primary tumor was diagnosed b...
متن کاملThe role of postoperative radiotherapy (PORT) in combined small cell lung cancer (C-SCLC)
PURPOSE To explore the value of radiotherapy in C-SCLC patients, especially in those receiving a radical resection. RESULTS The differences of survivals between the postoperative radiotherapy (PORT) and non-PORT groups were not statistically significant. But analyzing the benefits in subgroups, PORT significantly improved OS (p = 0.015), DFS (p = 0.026), LRFS (p = 0.008) and DMFS (p = 0.030) ...
متن کاملAngiogenesis inhibitors for the treatment of small cell lung cancer (SCLC)
BACKGROUND This study aimed to assess the effectiveness and safety of angiogenesis inhibitors for the treatment of patients with small cell lung cancer (SCLC) via meta-analysis. METHODS Electronic databases including PubMed, Embase, and Cochrane Library were searched to look for eligible studies through February 1, 2016. RCTs comprising angiogenesis inhibitors and nonangiogenesis inhibitors f...
متن کاملHealth Organization (WHO) classification, lung cancer can be divided into two major classes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC
It is known that the cause of cancer could be due to the gain of function of an oncoprotein (OCP) or the lost of function of a tumor suppressor protein (TSP). These proteins are potential targets for drugs. Lung cancer is one of the leading causes of death in Taiwan. In this study, differential expressed genes (DEGs) are identified, using the Bioconductor package, via expression dataset generat...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2018
ISSN: 1556-0864
DOI: 10.1016/s1556-0864(18)30355-1